Study: Side effects emerge after approval for many US drugs

FILE - This Feb. 19, 2013, file photo, shows OxyContin pills arranged for a photo at a pharmacy in Montpelier, Vt. More than 28,000 Americans died from overdosing on opiates in 2014, a record high for the nation. That’s 78 people per day, a number that doesn’t include the millions of family members, first responders and even taxpayers who feel the ripple of drug addiction in their daily lives. A rise in prescription painkillers is partially to blame: The sale of these drugs has quadrupled since 1999, and so has the number of Americans dying from an addiction to them. When prescriptions run out, people find themselves turning to the cheaper alternative heroin and, increasingly, the even more deadly drug fentanyl. (AP Photo/Toby Talbot, File)

CHICAGO (AP) – Almost one-third of new drugs approved by U.S. regulators over a decade ended up later with warnings about sometimes serious side effects.

That’s according to a new analysis published Tuesday in the Journal of the American Medical Association.

It involves all 222 prescription drugs approved by the Food and Drug Administration from 2001 to 2010. Researchers looked at potential problems that cropped up during routine monitoring that’s done once a medicine is on the market. There were safety issues with 71 drugs including top-sellers for depression, rheumatoid arthritis, infections and blood clots.

Three drugs were withdrawn and black-box warnings and less serious safety announcements were issued for dozens of other drugs.

Critics say the study raises questions about how thoroughly drugs are tested.

The FDA says it’s reviewing the results.

(Copyright 2017 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.)

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